文章摘要
| 许小强,黄敬耀,赵涛,涂秀英,黄佩蓓,高书亮,肖百全,罗荣,赵向峰.二精丸总多糖抗长期应激大鼠学习记忆障碍的作用机制[J].江西中医药大学学报,2007,(4):54-57. |
| 二精丸总多糖抗长期应激大鼠学习记忆障碍的作用机制 |
| Mechanism of Total Polysaccharides in Erjing Pill on Long-term Stress-induced Cognitive Deficits |
| 投稿时间：2007-04-17 修订日期：2007-04-17 |
| DOI： |
| 中文关键词: 肾阴虚,Morris水迷宫,二精丸,总多糖,激素水平,AchE |
| 英文关键词: Kidney-YIN deficiency,Morris water maze,Total polysaccharides,Hormone level,AchE |
| 基金项目:国家自然科学基金资助项目(30360123) |
| 许小强,黄敬耀,赵涛,涂秀英,黄佩蓓,高书亮,肖百全,罗荣,赵向峰 |
| 江西中医学院药理教研室 南昌330006 |
| 摘要点击次数: 4451 |
| 全文下载次数: 4936 |
| 中文摘要: |
| 目的探讨二精丸总多糖抗长期应激大鼠学习记忆障碍的作用机制.方法采用长期激怒应激法造模,二精丸总多糖灌胃,给药结束后用Morris水迷宫法测定各组实验大鼠的学习记忆能力;采用酶联免疫法测定大鼠血清雌二醇(E2)、睾酮(T)、皮质酮(CORT)、E2/T值以及海马部位乙酰胆碱酯酶(AchE)含量.结果二精丸总多糖组与模型组相比,平均潜伏期明显缩短(P＜0.05),搜索方式明显改变,游泳路径显示在中环区和中心区百分比增加(P＜0.05),平台区穿越次数增多(P＜0.05;E2和E2/T值明显降低(P＜0.05) |
| 英文摘要: |
| Objective:To study the mechanism of total polysaccharides in Erjing Pill on long-term stress-induced cognitive deficits.Methods:Model rats of kidney-YIN deficiency were made by using the method of long-term stress,Morris water maze was used to determine the cognition ability of different rats,then we used euzymelinked immunosorbent assay to determine the content of E2,T,CORT,E2/T in serum and AchE in hippocampus(HIP).Results:Compared to model group,total polysaccharides in Erjing Pill can shortened obviously mean incubation period(P<0.05)and changed obviously the way of searching,it increased obviously the sector percentage distribution of swimming pathway disclosed in middle ring zone and center zone(P<0.05)and the frequency of passing through plateau region(P<0.05);it Lowered obviously the content of E2 and E2/T(P<0.05),it heightened obviously the content of T and CORT(P<0.05),meanwhile it also shortened the activity of AchE in HIP(P<0.05).Conclusion:Total polysaccharides in Erjing Pill could elevate the cognition ability of model rats,lowering the content of E2 and E2/T,heightening the content of T and CORT,restraining the activity of AchE in HIP. |
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