文章摘要
| 张力,李海英,吴式琇,吴建波,韩义香.苦参碱对人鼻咽癌CNE2细胞增殖的抑制作用研究[J].江西中医药大学学报,2009,21(2):54-56. |
| 苦参碱对人鼻咽癌CNE2细胞增殖的抑制作用研究 |
| An Experimental Study of the Inhibiting Effect of matrine on Human nasopharyngeal carcinoma cells line CNE2 Proliferation |
| 投稿时间：2009-02-11 |
| DOI： |
| 中文关键词: 苦参碱；鼻咽癌细胞；增殖 |
| 英文关键词: matrine; human nasopharyngeal carcinoma cell; proliferation |
| 基金项目: |
| 张力,李海英,吴式琇,吴建波,韩义香 |
| 温州医学院附属第一医院,温州325000 |
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| 中文摘要: |
| 目的：观察苦参碱对人鼻咽癌CNE2细胞增殖的影响。方法：采用倒置显微镜观察苦参碱对鼻咽癌CNE2细胞形态的影响；采用CCK-8法检测苦参碱对鼻咽癌CNE2细胞生长的影响。结果：苦参碱处理后CNE2细胞形态发生改变，细胞皱缩，变小变圆，空泡明显。苦参碱能抑制鼻咽癌CNE2细胞的增殖。在实验浓度范围内，随着剂量的增加，抑制作用更加明显；同一剂量下，72 h内药物作用时间越长，抑制作用越明显。结论：苦参碱能够抑制鼻咽癌CNE2细胞的增殖。 |
| 英文摘要: |
| Objective: To study the effect of matrine on human nasopharyngeal carcinoma cell Line CNE2 Proliferation.Methods: Morphological changes of matrine on CNE2 cells were observed by light microscope.Proliferation of matrine on CNE2 cells was measured by CCK-8 colorimetric assay after treated by various concentrations of matrine.Results: Morphological changes of matrine on CNE2 cells: cell shrinkage,cell size reduction and turn round,cytoplasmic vacuolar changes.Matrine at a concentration between 0.5 mg/ ml and 2.0 mg/ ml inhibited the proliferation of CNE2 cells in dose - dependent manner.From 0h to 72 h,matrine with same concen-tration inhibited the proliferation of CNE2 cells in time-dependent manner.Conclusion: Matrine can specially inhibit proliferation of CNE2 cells. |
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