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.补肾活血汤治疗绝经后骨质疏松症 63 例临床观察[J].江西中医药大学学报,2024,36(2):55-57.
补肾活血汤治疗绝经后骨质疏松症 63 例临床观察
Clinical Observation of Bushen Huoxue Decoction in Treating 63 Cases of Postmenopausal Osteoporosis
  
DOI:10.20140/j.2095-7785.2024.02.15
中文关键词: 补肾活血汤;绝经后骨质疏松症;骨密度;骨代谢;炎症因子
英文关键词: Bushen Huoxue Decoction; Postmenopausal Osteoporosis; Bone Mineral Density; Bone Metabolism; Inflammatory Factors
基金项目::江西省中医药管理局科技计划项目(2020B0030);江西省卫生计生委中医药科研项目(2018A156,2018A085)
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中文摘要:
      目的:研究补肾活血汤治疗绝经后骨质疏松症(PMOP)的临床疗效及其作用机制。方法:采用回顾性研究,将 120 例 PMOP 患者按治疗方法分为对照组 57 例和观察组 63 例。对照组采用基础治疗,观察组在对照组基础上加服补肾活血汤。治 疗 3 个月后,根据腰椎和髋部骨密度(BMD)、骨代谢指标及炎症因子评价 2 组临床疗效。结果:治疗后,观察组总有效率为 80.95%,高于对照组的 64.91%,差异有统计学意义(P<0.05)。2 组腰椎和髋部 BMD、骨钙素(BGP)、Ⅰ型原胶原氨基端延 长肽(PINP)、胰岛素样生长因子结合蛋白 -3(IGFBP-3)水平均高于治疗前,且观察组高于对照组,差异均有统计学意义 (P<0.05);2 组Ⅰ型胶原羧基端肽 β 特殊序列(β-CTx)、超敏 C 反应蛋白(hs-CRP)、趋化因子配体 3(CCL3)水平均低 于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:补肾活血汤治疗 PMOP 可提高临床疗效,改善患者 BMD,其机制可能是通过抑制骨吸收、加快骨形成以及降低炎症反应等发挥作用
英文摘要:
      Objective: To explore the clinical efficacy and mechanism of Bushen Huoxue Decoction in the treatment of postmenopausal osteoporosis. Methods: One hundred and twenty patients with postmenopausal osteoporosis were divided into control group (57 cases) and observation group (63 cases) by using retrospective study. The control group was treated with basic treatment, the observation group was given Bushen Huoxue Decoction on the basis of the control group. After 3 months of treatment, the clinical efficacy of the two groups was evaluated according to bone mineral density of lumbar spine and hip, bone metabolism indexes and inflammatory factors. Results: The total effective rate in the observation group was 80.95%, which was higher than that in the control group (64.91%), with statistical significant (P<0.05). Compared with before treatment, the levels of BMD, BGP, PINP, IGFBP-3 were significantly increased in both groups after treatment. The above indexes in the observation group were significantly higher than those in the control group at the same time, with statistical significant (P<0.05). Compared with before treatment, the levels of β-CTx, hs-CRP and CCL3 in the two groups were significantly decreased. The above indexes in the observation group were significantly lower than those in the control group, with statistical significant (P<0.05). Conclusion: Bushen Huoxue Decoction can improve the clinical efficacy and BMD of patients with PMOP, which may play a role by inhibiting bone resorption, accelerating bone formation and reducing inflammatory response.
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