文章摘要
| 李雅方 安香霖 李启明 潘华平 鲁颖 李硕.《黄帝内经》肾藏志理论与补肾法治疗抑郁症的Meta 分析[J].江西中医药大学学报,2026,38(1):31-36. |
| 《黄帝内经》肾藏志理论与补肾法治疗抑郁症的Meta 分析 |
| Meta-Analysis on the Kidney Storing the Will Theory from Huangdi Neijing and Kidney-Tonifying Therapy for Treating Depression |
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| DOI：10.20140/j.2095-7785.2026.01.08 |
| 中文关键词: 黄帝内经；肾藏志；补肾法；抑郁症；Meta 分析；系统评价 |
| 英文关键词: Huangdi Neijing; Kidney Storing The Will; Kidney-Tonifying Therapy; Depression; Meta-Analysis; Systematic Review |
| 基金项目:江西省自然科学基金项目（20252BAC200556）；江西中医药大学首批校级科技创新团队项目（CXTD22016）；江西中医药大学博士启动基
金项目（2020BSZR013）。 |
| 作者 | 单位 | | 李雅方1,2 安香霖3 李启明4 潘华平3,5 鲁颖6 李硕3 | 1 . 江西中医药大学江西省中医药管
理局中医心理与脑科学重点研究室 南昌 330004；2 . 江西中医药大学人文学院 南昌 330004；3 . 江
西中医药大学临床医学院 南昌 330006；4 . 江西中医药大学岐黄国医书院 南昌 330025；5 . 江西中
医药大学癌症研究中心 南昌 330004；6 . 福建中医药大学中西医结合研究院 福州 350122 |
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| 中文摘要: |
| 目的：探讨《黄帝内经》肾藏志理论，系统评价中医补肾法治疗抑郁症的有效性与安全性，以期为补肾法治疗抑郁
症提供理论与循证依据。方法：计算机检索Cochrane library、Pubmed、EMbase、中国知网、维普、万方等中外文数据库，收
集有关补肾法治疗抑郁症的临床随机对照研究，检索时间为建库至2023 年3 月28 日。由2 位研究者独立筛选文献、提取
资料并进行文献质量评价，运用RevMan 5.4.1 软件进行Meta 分析。结果：共纳入17 篇文献，收集病例1 809 例。Meta 分析
结果显示，补肾法治疗抑郁症的临床症状有效率、汉密尔顿抑郁量表减分量显著高于常规西药组［OR=2.58，95%CI（1.81，
3.68），P<0 .000 01）］、［MD=2 .80，95%CI（1.01，4.59），P=0 .002］，补肾法治疗抑郁症的不良反应发生率显著低于常规西
药组［OR=0 .37，95%CI（0.27，0.52），P<0 .000 01）］。结论：肾虚志衰是抑郁症发病的重要基础，补肾强志可以有效治疗
抑郁症，且不良反应发生率更低。受研究质量和数量限制，上述结论尚需更多高质量、多中心、大样本研究予以验证。 |
| 英文摘要: |
| Objective: To explore the theory of "the kidney storing the will" (Shen Cang Zhi) from Huangdi Neijing, and to systematically
evaluate the efficacy and safety of Kidney-Tonifying Therapy (Bushen Fa) in treating depression, aiming to provide theoretical and evidence
based support for this approach. Methods: Randomized controlled trials (RCTs) investigating Kidney-Tonifying Therapy for depression were
retrieved from both Chinese and English databases (Cochrane Library, PubMed, Embase, CNKI, VIP, Wanfang). The search period spanned
from the inception of each database to March 28, 2023. Two researchers independently screened the literature, extracted data, and assessed
the quality of the included studies. Meta-analysis was performed using RevMan software (version 5.4.1). Results: Seventeen studies involving
a total of 1,809 patients were included. Meta-analysis results showed that the Kidney-Tonifying Therapy group demonstrated significantly
higher overall clinical response rates [OR = 2.58, 95%CI (1.81, 3.68), P<0.000 01] and greater reductions in Hamilton Depression Rating
Scale (HAMD) scores [MD = 2.80, 95%CI (1.01, 4.59), P=0.002] compared to the conventional Western medicine group. Moreover, the
incidence of adverse reactions in the Kidney-Tonifying Therapy group was significantly lower than that in the conventional Western medicine
group [OR = 0.37, 95%CI (0.27, 0.52),P<0.000 01]. Conclusion: Kidney deficiency and weakness of the will (Shenxu Zhishuai) constitute an
important pathological basis for depression. Kidney-Tonifying and Will-Strengthening Therapy (Bushen Qiangzhi) is an effective approach in
treating depression and is associated with a lower incidence of adverse reactions. However, due to limitations in the quality and quantity of the
included studies,these findings require further validation through more high-quality,multi-center,large-scale RCTs. |
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