| 蔡而玮 赵诚 许圳鹏 林峰.基于“湿热论治、内外并治”的黄白胶囊联合消痔洗剂治疗混合痔术后并发症
临床观察[J].江西中医药大学学报,2026,38(1):51-55. |
| 基于“湿热论治、内外并治”的黄白胶囊联合消痔洗剂治疗混合痔术后并发症
临床观察 |
| Clinical Observation on Huangbai Capsule Combined with Xiaozhi Lotion in the Treatment of Postoperative Complications of Mixed Hemorrhoids Based on the Therapeutic Principles of "Damp-heat Treatment,Internal and External Treatment" |
| |
| DOI：10.20140/j.2095-7785.2026.01.12 |
| 中文关键词: 湿热论治；内外并治；黄白胶囊；消痔洗剂；混合痔；术后并发症；炎症因子 |
| 英文关键词: Treatment of Damp-heat; Internal and External Treatment; Huangbai Capsule; Xiaozhi Lotion; Mixed Hemorrhoids;
Postoperative Complications; Inflammatory Factor |
| 基金项目:福建中医药大学校管科研课题优势学科专项（X2022002-专项）。 |
| 作者 | 单位 | | 蔡而玮 赵诚 许圳鹏 林峰 | 福建中医药大学附属人民医院肛肠二科 福州 350004 |
|
| 摘要点击次数: 496 |
| 全文下载次数: 918 |
| 中文摘要: |
| 目的：以“湿热论治、内外并治”为指导思想，探究黄白胶囊联合消痔洗剂治疗混合痔术后并发症的临床疗效及
对炎症因子的影响。方法：将90 例混合痔术后患者采用随机数字表法分为黄白胶囊组、消痔洗剂组和联合治疗（黄白胶
囊+ 消痔洗剂）组，各30 例。记录3 组患者术后第3、7、14 天肛门水肿、疼痛、出血情况，完成中医证候积分统计。采用
ELISA 法检测3 组NF-κB、IFN-γ表达情况，利用HE 染色观察3 组创面肉芽组织情况。结果：3 组均能有效缓解混合痔术
后疼痛、水肿、出血症状及改善中医证候。术后第14 天比较，联合治疗组改善情况优于消痔洗剂组及黄白胶囊组，差异有统
计学意义（P<0 .05）；3 组愈合时间比较，联合治疗组短于消痔洗剂组及黄白胶囊组，差异有统计学意义（P<0 .05）；3 组临
床总有效率比较无显著性差异（P>0 .05）。术后第14 天，3 组NF-κB、IFN-γ表达水平均有下降，且联合治疗组低于其他
2 组，差异均有统计学意义（P<0 .05）。术后第14 天HE 染色光镜下观察发现，联合治疗组成纤维细胞分布相对密集且有序，
清晰可见胶原纤维生成及较多毛细血管生成。结论：以“湿热论治、内外并治”理论为指导的黄白胶囊+ 消痔洗剂对混合痔
术后并发症及抑制炎症因子表达的效果更优，值得临床推广。 |
| 英文摘要: |
| Objective: Taking "Damp-heat treatment, both internal and external treatment" as the guiding ideology to study the clinical
effect of Huangbai Capsule combined with Xiaozhi Lotion on postoperative complications of mixed hemorrhoids and its influence on
inflammatory factors. Methods: 90 cases of mixed hemorrhoid after operation were randomly divided into three groups: Huangbai Capsule
Group (30 cases), Xiaozhi Lotion Group (30 cases) and Huangbai Capsule combined with Xiaozhi Lotion Group (30 cases). The changes of
anal edema,pain and bleeding were recorded on the 3rd,7th and 14th day after operation in three groups, and the statistics of TCM syndrome
were completed. The granulation tissue of each group was detected by HE, and the expression of NF-κB and IFN- γwas detected by
ELISA. Results: All the three groups can effectively alleviate the pain, edema, bleeding symptoms and improve the symptoms of traditional
Chinese medicine mixed hemorrhoids; On the 14th day after operation, Huangbai Capsule combined with Xiaozhi Lotion Group was better
than Xiaozhi Lotion Group and Huangbai Capsule Group, the difference was significant (P<0.05); The healing time of Huangbai Capsule
combined with Xiaozhi Lotion group was significantly shorter than that of Xiaozhi Lotion group and Huangbai Capsule Group (P<0.05);
There was no significant difference in the total effective rate. On the 14th day after operation, the expression of NF-κB and IFN-γin the
three groups were all decreased, but that in the Huangbai Capsule combined with Xiaozhi Lotion group was significantly lower than that in
the other two groups (P<0.05). On the 14th day after operation, the fibroblasts in the Huangbai capsule combined with Xiaozhi lotion group
were found to be relatively dense and orderly, and collagen fibers and more capillary were clearly seen. Conclusion: Huangbai Capsule
and Xiaozhi Lotion, guided by the theory of "Damp-heat treatment, internal and external treatment", have better effect on the postoperative
complications of mixed hemorrhoids and inhibiting the expression of inflammatory factors. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |