文章摘要
| 闫东升,周小琳,石和元,丁凤敏,王平（指导）.越鞠丸对抑郁症模型小鼠行为学、5-羟色胺及血浆皮质醇的影响[J].江西中医药大学学报,2007,(2):64-67. |
| 越鞠丸对抑郁症模型小鼠行为学、5-羟色胺及血浆皮质醇的影响 |
| The Effect of Yueju Pill to the Ethology, 5 - HT and Blood Plasm Cortisol of Depressive Disorder Mouse |
| 投稿时间：2006-11-06 修订日期：2006-11-06 |
| DOI： |
| 中文关键词: 郁证,越鞠丸,抑郁症,行为学指标,5-羟色胺,皮质醇 |
| 英文关键词: Depressed Syndrome,Yueju Pill,Depressive Disorder,the index of ethology,5-HT,Cortisol |
| 基金项目: |
| 闫东升,周小琳,石和元,丁凤敏,王平（指导） |
张仲景国医学院 湖北中医学院在职硕士研究生武汉473003(闫东升)
，湖北中医学院 2003级硕士研究生武汉473003(周小琳，石和元)
，湖北中医学院 2004级硕士研究生武汉473003(丁凤敏)
，湖北中医学院 武汉473003(王平)
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| 中文摘要: |
| 目的:观察越鞠丸对慢性轻度不可预见性的应激抑郁(CUMS)小鼠模型的影响,揭示该方对抑郁症的药效及作用机理。方法:实验分组:健康昆明种小鼠随机分为4组,即空白对照组(简称空白组)、模型组、阳性药物对照组(简称对照组)、越鞠丸组,每组12只。越鞠丸组小鼠给予该方水煎液灌胃;对照组予阿米替林等容积混悬液灌胃;空白组、模型组均予等容积生理盐水灌胃,连续18天。记录5分钟小鼠自主活动次数,并记录5分钟内小鼠的激惹次数及检测5-HT的含量及血浆皮质醇浓度。结果:越鞠丸组小鼠行为学指标明显改善,疗效与对照组比较无显著 |
| 英文摘要: |
| Objective: Observe the effect of Yueju pill to chronic unpredictable mild stress(CUMS) mouse,to reveal the drug action and the mechanism of the medicine.Methods: Divide into groups: healthy kunming mouse were divide into 4 groups,that is blank control group(to abbreviate blank group),model,masculine drug group(to abbreviate control group) and Yueju pill group,12 mouse per group.Yueju pill group were lavaged with the decoct of it,control group were labaged with amitriptyline,blank and model group were both lavaged with normal saline,continue 18 days.Record the autonomic activities frequency,and record irritation frequency in 5 minutes,and detect the content of 5-HT and plasma cortisol.Results: the index of ethology of mouse was improved treated with Yueju pill,contrast to the control group,the curative effect has no significant difference(P<0.05).Conclusions: increasing the level of 5-HT of brain tissue in depressive disorder mouse and decreasing the content of plasma cortisol may be the mechanism of Yueju pill. |
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