文章摘要
| 冯剑,尤艳利, 周爽, 陈宝谨,李白羽,方凡夫,丁邦友,袁凌松.电针水沟穴对高血压性脑出血模型大鼠神经元保护作用的动态观察[J].江西中医药大学学报,2009,21(2):43-46. |
| 电针水沟穴对高血压性脑出血模型大鼠神经元保护作用的动态观察 |
| Dynamic Detection of Neuron Protective Effect of Electroacupuncture at Shuigou on Hypertensive Intracerebral Hemorrhage Model of Rats |
| 投稿时间：2008-11-19 |
| DOI： |
| 中文关键词: 电针；水沟穴；脑出血；神经元保护作用 |
| 英文关键词: Electroacupuncture; Shuigou (RN 26); Intracerebral Hemorrhage; Neuron Protective Effect |
| 基金项目:基金项目：国家自然科学基金资助(30400608，30672714)，上海市重点学科建设资助 (T0302) |
| 冯剑1,尤艳利1, 周爽1, 陈宝谨2,李白羽1,方凡夫1,丁邦友2,袁凌松2 |
| 1.第二军医大学中医系,上海 200433,2.上海中医药大学,上海201203 |
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| 中文摘要: |
| 目的:探讨电针水沟穴对急性高血压性脑出血模型大鼠脑组织超微结构的影响。方法：参照胶原酶加肝素脑内尾状核联合注射的方法造模。WKY大鼠分为6 h、1 d、3 d、7 d对照组。受试SHR大鼠分为模型6 h、1 d、3 d、7 d组；假手术6 h、1 d、3 d、7 d组；电针6 h、1 d、3 d、7 d治疗组。分别在6 h、1 d、3 d、7 d用光镜和电镜观察各组大鼠脑组织结构的变化情况。结果：模型组大鼠6h即出现明显的脑组织超微结构改变，模型1 d组超微结构病变进一步加重，模型3 d组较1 d模型组脑 |
| 英文摘要: |
| Objective :To study the effect of e1ectroacupuncture (EA) at Shuigou (RN 26) on ultrastructure in hypertensive intracerebral hemorrhage (ICH) rats.Methods: Experimental hypertensive ICH model of rats were established by injecting collagenase and heparin into right caudate nucleus of spontaneously hypertensive rats using stereotaxis technique.WKY rats were divided into 6 hours,1 day,3 days group and 7 days group after injecting physiological saline into right caudate nucleus,and spontaneously hypertensive rats (SHR) were divided into model groups (6 hours,1 day,3 days,7 days),sham operation groups (6 hours,1 day,3 days,7 days) and the EA groups (6 hours,1 day,3 days,7 days).Electroacupuncture at Shuigou (RN 26) treated EA groups every day.The changes of brain tissue ultrastructure in every group were observed under light and electron microscope at 6 hours,1 day,3 days,and 7 days after operation.Results: In model groups,significant change of brain tissue ultrastructure appeared at 6 hours after operation and the lesion aggravate at 1 days.At 3 days,amelioration of the lesion appeared,and at 7 days the lesion became similar to that of 6 hours group.EA group in all time points showed significant improvement in organelle swelling degree of cerebral cortical neurons compared with the model group,and at 7 days the membrane and most of organelles of nerve cells were perfect,and bilayer structure of nucleus were clear.However,some mitochondria swelled,and there were a little mult heterochromatin in some nerve cells.Conclusion: The therapy of e1ectroacupuncture at Shuigou (RN 26) can improve brain tissue ultrastructure in hypertensive ICH model rat,which may be one of mechanisms of promoting neuronal function restoration. |
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